After the great Plague descended, the world population was decimated, and their genetics damaged beyond repair. The Lasters wait hopelessly for their genes to self-destruct. The Splicers pay for expensive treatments that might prolong their life. The plague-resistant True Borns are as mysterious as they are feared. And then there's Lucy Fox and her identical twin sister, Margot. After endless tests, no one wants to reveal what they are. When Margot disappears, a desperate Lucy has no choice but to put her faith in the True Borns, including the charismatic leader, Nolan Storm, and the beautiful but deadly Jared, who tempts her as much as he infuriates her. As Lucy and the True Borns set out to rescue her sister, they stumble upon a vast conspiracy stretching from Dominion's street preachers to shady Russian tycoons. But why target the Fox sisters?